3930-20-9 MSDS - Sotalol
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Sotalol

Identification
Name Sotalol
CAS Registry Number 3930-20-9
Synonyms SOTALOL;4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilid;4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide;beta-Cardone;dl-sotalol
Molecular Structure Sotalol   3930-20-9
Molecular Formula C12H20N2O3S
Molecular Weight 272.36
Hazard Codes: Details
Risk Statements: 36/37/38
Safety Statements: 26-36
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
3930-20-9.pdf
Sotalol
Sotalol.svg
Sotalol ball-and-stick.png
Clinical data
Trade names Betapace, other
AHFS/Drugs.com Monograph
MedlinePlus a693010
Pregnancy
category
  • AU: C
  • US: B (No risk in non-human studies)
Routes of
administration
by mouth
Drug class beta blocker
ATC code
  • C07AA07 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • CA: ℞-only
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability 90–100%[1]
Metabolism Not metabolized[1]
Biological half-life 12 hours[1]
Excretion Kidney
Mammary gland (In lactating females)[1]
Identifiers
CAS Number
  • 3930-20-9 YesY
PubChem CID
  • 5253
IUPHAR/BPS
  • 7297
DrugBank
  • DB00489 YesY
ChemSpider
  • 5063 YesY
UNII
  • A6D97U294I
KEGG
  • D08525 YesY
ChEMBL
  • CHEMBL471 YesY
Chemical and physical data
Formula C12H20N2O3S
Molar mass 272.3624 g/mol
3D model (JSmol)
  • Interactive image
Chirality Racemic mixture
  (verify)

Sotalol is a medication used to treat heart arrhythmias. The U.S. Food and Drug Administration advises that sotalol only be used for serious arrhythmias, because its prolongation of the QT interval carries a small risk of life-threatening torsade de pointes.[2]

It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties.[3][4]

Sotalol was discovered in 1960, became widely used in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.[5]


 







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