3930-20-9 MSDS - Sotalol
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Sotalol

Identification
Name Sotalol
CAS Registry Number 3930-20-9
Synonyms SOTALOL;4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilid;4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide;beta-Cardone;dl-sotalol
Molecular Structure Sotalol   3930-20-9
Molecular Formula C12H20N2O3S
Molecular Weight 272.36
Hazard Codes: Details
Risk Statements: 36/37/38
Safety Statements: 26-36
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
3930-20-9.pdf
Sotalol
Sotalol.svg
Sotalol ball-and-stick.png
Systematic (IUPAC) name
(RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
Clinical data
Trade names Betapace
AHFS/Drugs.com monograph
MedlinePlus a693010
Pregnancy
category
  • AU: C
  • US: B (No risk in non-human studies)
Legal status
  • AU: Prescription Only (S4)
  • CA: -only
  • UK: Prescription-only (POM)
  • US: -only
Routes of
administration
oral
Pharmacokinetic data
Bioavailability 90–100%[1]
Metabolism Not metabolized[1]
Half-life 12 hours[1]
Excretion Renal
Lactic (In lactating females)[1]
Identifiers
CAS Registry Number
3930-20-9 YesY
ATC code
C07AA07
PubChem CID 5253
DrugBank DB00489 YesY
ChemSpider 5063 YesY
UNII A6D97U294I YesY
KEGG D08525 YesY
ChEMBL CHEMBL471 YesY
Chemical data
Formula C12H20N2O3S
Molecular mass
272.3624 g/mol
 YesY (what is this?)  (verify)

Sotalol is a drug used in individuals with rhythm disturbances of the heart (cardiac arrhythmias). It is a non-selective competitive beta-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties.[2][3] Originally discovered in 1960, sotalol became widely used first as a beta blocker in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.[4] Due to the dual action of sotalol, it is often used preferentially to other beta blockers as treatment for both ventricular fibrillation and ventricular tachycardia.[2][5]

Trade names for Sotalol include Betapace and Betapace AF (Berlex Laboratories), Sotalex and Sotacor (Bristol-Myers Squibb), and Sotylize (Arbor Pharmaceuticals).[6] The U.S. Food and Drug Administration advises that sotalol only be used for serious arrhythmias, because its prolongation of the QT interval carries a small risk of life-threatening torsade de pointes.[6]


 






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