3930-20-9 MSDS - Sotalol
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Sotalol

Identification
Name Sotalol
CAS Registry Number 3930-20-9
Synonyms SOTALOL;4'-[1-Hhydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]metahnesulfonanilide;4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide;4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilid;4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilide;beta-Cardone;dl-sotalol
Molecular Structure Sotalol   3930-20-9
Molecular Formula C12H20N2O3S
Molecular Weight 272.36
Hazard Codes: Details
Risk Statements: 36/37/38
Safety Statements: 26-36
Supplier
Lightchem Inc
Supply Precious metal catalyst
OLED Materials etc.
www.lightchem.com
 
Wiki & MSDS
3930-20-9.pdf
Sotalol
Sotalol.svg
Sotalol ball-and-stick.png
Systematic (IUPAC) name
(RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide
Clinical data
Trade names Betapace
AHFS/Drugs.com monograph
MedlinePlus a693010
Pregnancy cat. B (US)
Legal status Prescription only
Routes oral
Pharmacokinetic data
Bioavailability >95%
Metabolism Not metabolized[citation needed]
Half-life 12 hours
Excretion Renal
Lactic (In lactating females)
Identifiers
CAS number 3930-20-9 YesY
ATC code C07AA07
PubChem CID 5253
DrugBank DB00489
ChemSpider 5063 YesY
UNII A6D97U294I YesY
KEGG D08525 YesY
ChEMBL CHEMBL471 YesY
Chemical data
Formula C12H20N2O3S 
Mol. mass 272.3624 g/mol
 YesY (what is this?)  (verify)

Sotalol is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to treat hypertension in some individuals. It is a non-selective competitive β-adrenergic receptor blocker that also exhibits Class III antiarrhythmic properties by its inhibition of potassium channels.[1][2] Because of this dual action, Sotalol prolongs both the PR interval and the QT interval. Originally discovered around 1960, sotalol became widely used first as a β-blocker in the 1980s, and its function as an antiarrhythmic drug was discovered soon after.[3] Due to the dual action of sotalol, it is often used preferentially to other β-blockers as treatment for both ventricular fibrillation and ventricular tachycardia.[1][4]

Trade names for Sotalol include Betapace and Betapace AF (Berlex Laboratories), and Sotalex and Sotacor (Bristol-Myers Squibb).


 






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